iatrochemist

Around the year 1643, Joan Baptista van Helmont, a Flemish chemist, alchemist and physician who had devised what he claimed to be a new form of medicine, proposed a ‘challenge’ to traditional Galenic physicians to compare treatment of fever by traditional methods and by a regime which did not involve bloodletting and purging. Two groups of patients were to be treated and ‘casting of lots’ was to be used – in some way not specified in detail – to decide who received which treatment. This ‘challenge’ has been regarded as the first proposal for the use of randomisation in a clinical trial.