We present a patient with liver cirrhosis, and portal hypertensive gastropathy who was transfusion-dependent due to chronic gastrointestinal blood loss. Wireless capsule endoscopy revealed bleeding from extensive vascular ectatic lesions in the small bowel and right colon as well as from the stomach. We discuss briefly the recent literature relating to chronic gastrointestinal bleeding due to portal hypertensive enteropathy, the diagnosis of this condition, and the use of TIPSS in treatment.