This symposium provided an update in various areas within the fields of diabetes and endocrinology. Topics included the effects of diet and exercise on the metabolic syndrome and cardiovascular disease; programmes to decrease the incidence of diabetes; updates in the genetics of phaeochromocytoma, obesity and type 2 diabetes; the use of pegvisomant in acromegaly and incretin-based therapies in type 2 diabetes; and the relative strengths and weaknesses of bisphosphonates and HRT as treatment for post-menopausal osteoporosis.