Journal Mobile

K Peeroo, A Clark
Journal Issue: 
Volume 40: Issue 4: 2010




The  prevalence  of  proteinuria  in  patients  presenting  acutely  with oedema  due  to  heart  failure  has  not  been  studied  extensively.  Recent  evidence from the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM) trial suggests that there is a high prevalence of albuminuria in chronic heart failure patients. We set out to investigate the prevalence of proteinuria in  patients  presenting  with  fluid  retention  secondary  to  heart  failure. A  random collection  of  urine  albumin–creatinine  ratios  (ACRs)  in  successive  patients  was used to quantify proteinuria. Out of a sample of 19 patients, seven had no detectable albuminuria,  eight  had  microalbuminuria  and  four  had  macroalbuminuria. We  did not find any relation between urine ACR and age, serum urea or serum creatinine. Moreover, we did not find a higher prevalence of albuminuria with increasing age or the presence of diabetes mellitus. In conclusion, the clinical significance of this common finding in patients presenting with fluid retention is not clear, and further research is warranted to clarify its prognostic value.