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Author(s): 

Madhavi Karri1, Balakrishnan Ramasamy2, Santhosh Perumal3, Karthik Thamarai Kannan4

Author Affiliations: 

1Assistant Professor, 2Professor and Head of Department, 3Assistant professor, 4Resident, Department of Neurology, PSG institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India

Correspondence to: 

Madhavi Karri, Department of Neurology, PSG institute of Medical Sciences and Research, PSG Hospitals, Peelamedu Coimbatore, Tamil Nadu 641004,, India

Email:
dr.madhavikarri@gmail.com

Journal Issue: 
Volume 50: Issue 3: 2020
Cite paper as: 
J R Coll Physicians Edinb 2020; 50: 305–6

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A 23-year-old female presented to a local physician with multiple episodes of vomiting. She had persistence of symptoms despite symptomatic treatment. Magnetic resonance imaging (MRI) brain plain showed hyperintensities in bilateral dorsomedial thalamus, the periaqueductal gray area and tectum of the midbrain in T2-weighted and fluid-attenuated inversion recovery (FLAIR) images. (Figure 1 A,B,C,D). The findings were typical of Vitamin B1 (thiamine) deficiency (Wernicke’s encephalopathy). Intravenous thiamine was given and her symptoms resolved. Ten days later she presented with recurrence with worsening associated with hiccups and giddiness. Clinically she had left eye rapid afferent pupillary defect; the rest of the neurological examination was normal. Repeat MRI after ten days showed persistent findings of hyperintensities in the periaqueductal region and bilateral thalami (Figure 1 E, F, G, H) with no diffusion restriction and no contrast enhancement.

Figure 1 Magnetic resonance images: T2 fluid-attenuated inversion recovery (FLAIR) images (A, B) showing hyperintensities in bilateral dorsomedial thalamus (arrows) and T2-weighted images (C, D) showed hyperintensities in periaqueductal regions (triangular heads). Magnetic resonance images: T2 FLAIR images showing hyperintensities in the area postrema (E) (triangular head) and periaqueductal region (F, G) (arrowheads) and thalamus (H) (arrow).

On further probing, her history revealed that she had left eye ocular pain with diminution of vision four months previously. She was evaluated elsewhere and diagnosed with papillitis. Her brain and spine imaging were normal. Her symptoms resolved a week after being treated with intravenous and oral tapering steroids. She had a similar episode one month previously, where she was diagnosed with left eye optic neuritis and started on intravenous pulse steroids followed by oral steroid therapy.

With the history of two episodes of optic neuritis in the past, and with the current clinical event of area prostrema syndrome, she was evaluated for demyelinating illness, with neuromyelitis optica in particular. Her complete blood picture, blood glucose, electrolytes, renal and liver functions were normal. Her vitamin B1, B6, and B12 levels were normal. She was positive for IgG antibodies against aquaporin 4 (AQP4 autoantibodies). Cerebrospinal fluid (CSF) analysis was negative for oligoclonal bands and infections.

Brain involvement in neuromyelitis optica spectrum disorder (NMOSD) is known to have a variable prevalence ranging from 25% to 84%, and most of them are clinically silent.1 They typically involve periependymal regions, circumventricular regions, corpus callosum, brainstem, hypothalamus and optic chiasm.2 In this case, the radiological picture was atypical and rare for NMOSD (Table 1). These imaging findings were characteristic of thiamine deficiency but not specific for the same. Other conditions with similar imaging findings include multiple sclerosis, Miller-Fisher syndrome, Behçet’s disease, Leigh’s disease, primary cerebral lymphoma, paraneoplastic encephalitis and metabolic disorders like severe hypophosphataemia and acute methyl bromide intoxication.3 Hence, a detailed history with the clinical picture together with imaging findings is vital to make a concordant diagnosis.

Table 1 Similarities and differences between neuromyelitis optica and Wernicke’s encephalopathy

 

Similarities

Differences

   

Neuromyelitis optica

Wernicke’s encephalopathy

Clinical features

Encephalopathy or somnolence or confusion

Ataxia

Vomiting

Vertigo or giddiness

Optic neuritis

Transverse myelitis

Ophthalmoplegia

Radiological

Around the ventricles (more commonly third and fourth)

Periaqueductal area

Thalamus or medial thalamus

Cerebellum

Hypothalamus

Brainstem

Corpus callosum

Deep white matter

Spinal cord

Cloud-like enhancement

Mamillary bodies

Tectal plate

No enhancement

Histopathological

Astrocyte damage

Demyelination

Haemorrhage and cytotoxic oedema in astrocytes and neurons

Break of blood-brain barriers

Diagnostic

 

Aquaporin 4 antibody

Serum thiamine levels

Treatment

 

Intravenous pulse steroids, oral steroids, immunosuppressants, rituximab

Intravenous or oral thiamine

 

References:

1 Kim HJ, Paul F, Lana-Peixoto MA et al. MRI characteristics of neuromyelitis optica spectrum disorder: An international update. Neurology 2015; 84: 1165–73.

2 Dutra BG, Da Rocha AJ, Nunes RH et al.Neuromyelitis optica spectrum disorders: Spectrum of MR imaging findings and their differential diagnosis. Radiographics 2018; 38: 662.

3 Sechi G Pietro, Serra A. Wernicke’s encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol 2007; 6: 442–55.

Financial and Competing Interests: 
No conflict of interests declared
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